摘要：
In the computer-aided diagnosis system, the use of medical database data mining and knowledge discovery technology is of great significance and necessity of development. To understand the health status of left-behind children in ethnic minority areas, a questionnaire survey and computer-aided technology were used to diagnose and investigate the health status of left-behind children aged 6-12 years in Xiangxi, Hunan Province, such as body shape, physical function and personal cognition. The comparison results show that the body shape, function and perception of left-behind children are not optimistic. The countermeasures are to strengthen policy support, school physical education and the supervision consciousness of the guardian, make the government, schools and families form a joint force, establish a scientific work and leisure system, improve the quality of life, and effectively build the health level of left-behind children.
通讯机构：
[Yushun Gong] N;National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Changsha 410128, China<&wdkj&>Key Laboratory of Tea Science of Ministry of Education, Changsha 410128, China<&wdkj&>Key Laboratory for Evaluation and Utilization of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural Affairs of China, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Author to whom correspondence should be addressed.
摘要：
Sleep, a conservative evolutionary behavior of organisms to adapt to changes in the external environment, is divided into natural sleep, in a healthy state, and sickness sleep, which occurs in stressful environments or during illness. Sickness sleep plays an important role in maintaining energy homeostasis under an injury and promoting physical recovery. Tea, a popular phytochemical-rich beverage, has multiple health benefits, including lowering stress and regulating energy metabolism and natural sleep. However, the role of tea in regulating sickness sleep has received little attention. The mechanism underlying tea regulation of sickness sleep and its association with the maintenance of energy homeostasis in injured organisms remains to be elucidated. This review examines the current research on the effect of tea on sleep regulation, focusing on the function of tea in modulating energy homeostasis through sickness sleep, energy metabolism, and damage repair in model organisms. The potential mechanisms underlying tea in regulating sickness sleep are further suggested. Based on the biohomology of sleep regulation, this review provides novel insights into the role of tea in sleep regulation and a new perspective on the potential role of tea in restoring homeostasis from diseases.
通讯机构：
[Zhonghua Liu; Yushun Gong] A;Authors to whom correspondence should be addressed.<&wdkj&>National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Collaborative Innovation Center of Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China
关键词：
theanine;EGCG;hormesis;Reactive Oxygen Species (ROS);DAF-16
摘要：
Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea. Our previous report showed that induced hormesis was a critical determinant for the promotion of a healthy lifespan in Caenorhabditis elegans. In the present study, we investigated the anti-aging effects of the main active ingredients in green tea. We found that galloylated catechins (EGCG and epicatechin gallate) could extend the lifespan of C. elegans, while their metabolites (gallic acid, epicatechin, and epigallocatechin) could not. Interestingly, the combination with theanine, not caffeine, could alleviate the adverse effects induced by high-dose EGCG, including the promotion of lifespan and locomotor ability. This was due to the attenuation of the excess production of reactive oxygen species and the activation of DAF-16. These findings will facilitate further studies on the health benefits of tea active components and their interactions.
