Targeted Intracellular Controlled Drug Delivery and Tumor Therapy through in Situ Forming Ag Nanogates on Mesoporous Silica Nanocontainers

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成果类型：

期刊论文

作者：

Liu, Changhui;Zheng, Jing;Deng, Li;Ma, Cheng;Li, Jishan;...

通讯作者：

Yang, Ronghua

作者机构：

[Deng, Li; Liu, Changhui; Yang, Sheng; Ma, Cheng; Zheng, Jing; Yang, Ronghua; Li, Yinhui; Li, Jishan] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

[Liu, Changhui] Hunan City Univ, Dept Chem & Environm Engn, Yiyang 413000, Peoples R China.

[Yang, Sheng; Yang, Ronghua] Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Changsha 410004, Hunan, Peoples R China.

[Yang, Jinfeng; Wang, Jing] Cent S Univ, Xiangya Sch Med, Affiliated Canc Hosp, Changsha 410011, Hunan, Peoples R China.

通讯机构：

[Yang, Ronghua] H

Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

语种：

英文

关键词：

drug delivery;mesoporous silica nanoparticle;DNA;silver sphere;glutathione

期刊：

ACS Applied Materials & Interfaces

ISSN：

1944-8244

年：

2015

卷：

期：

页码：

11930-11938

DOI：

10.1021/acsami.5b01787

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21405038, 21135001, 21305036]; Foundation for Innovative Research Groups of NSFCNational Natural Science Foundation of China (NSFC) [21221003]; "973" National Key Basic Research ProgramNational Basic Research Program of China [2011CB91100-0]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities

机构署名：

本校为其他机构

院系归属：

材料与化学工程学院

摘要：

Targeting nanocontainers to the pathological zone and controlling release of their cargoes, in particular delivery of anticancer drugs to specific tumor cells in a targeted and controlled manner, remain the key challenges in drug delivery. This paper reports the development of a traceable and tumor-targeted intracellular drug release nanocontainer. The nanocontainer is obtained by in situ growth of silver nanoparticles (AgNPs) on the surfaces of mesoporous silica nanospheres (MSNs) using a DNA-templated process. Additionally, drug release from ...

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Targeted Intracellular Controlled Drug Delivery and Tumor Therapy through in Situ Forming Ag Nanogates on Mesoporous Silica Nanocontainers

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