期刊论文

Xia Li-Qiu

中文

化学学报

0567-7351

2008

66

1

108-111

10.3321/j.issn:0567-7351.2008.01.018

国家自然科学基金（Nos.30570050,30670052）； 国家“863”计划（No.2006AA02Z187）资助项目；

本校为其他机构

运用生物信息学软件对苏云金芽孢杆菌毒素Cry1Aa，Cry2Aa，Cry3Aa和Cry4Aa的基本参数、一级结构、二级结构、三级结构、跨膜区和表面电势进行了预测比较．它们在一级结构上有较大差异，但二级结构和跨膜区相似，三级结构中各毒素的结构域Ⅰ之间基本相似，结构域Ⅱ之间差异较大，其中Cry2Aa为差异最大成员．4种毒素的表面电势分布不同，毒素之间的结构相似性和差异性与其作用机理和杀虫特异性有关。

The primary parameters, secondary and tertiary structures and transmembrane regions of Bacillus thuringiensis toxins, Cry1Aa, Cry2Aa, Cry3Aa and Cry4Aa, were compared in bioinformatics. Considerable differences were found among the four toxins compared with each other in the primary structure, and many similarities were in the secondary structure and transmembrane regions. The structural diversity is smallest in domain I, domain II is the most divergent domain, and Cry2Aa is the most divergent member. The surface potentials over the four toxins were different. Those structural diversity and si...