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INTS-MFS: A novel method to predict microRNA-disease associations by integrating network topology similarity and microRNA function similarity

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成果类型:
期刊论文
作者:
Cao, Buwen*;Luo, Jiawei*;Xiao, Sainan;Zhao, Kai;Yang, Shuling
通讯作者:
Cao, Buwen;Luo, Jiawei
作者机构:
[Xiao, Sainan; Yang, Shuling; Cao, Buwen; Zhao, Kai] Hunan City Univ, Coll Informat & Elect Engn, Yiyang 413000, Peoples R China.
[Luo, Jiawei] Hunan Univ, Coll Comp Sci & Elect Engn, Changsha 410082, Hunan, Peoples R China.
通讯机构:
[Cao, Buwen; Luo, Jiawei] H
Hunan City Univ, Coll Informat & Elect Engn, Yiyang 413000, Peoples R China.
Hunan Univ, Coll Comp Sci & Elect Engn, Changsha 410082, Hunan, Peoples R China.
语种:
英文
关键词:
Disease-related miRNA;Functional similarity;MiRNA-disease association;Network topological similarity
期刊:
生物细胞(英文)
ISSN:
0327-9545
年:
2022
卷:
46
期:
3
页码:
837-845
基金类别:
Funding Statement: This work was supported in part by the National Natural Science Foundation of China under Grants 61873089, 62032007 and the Key Project of the Education Department of Hunan Province under Grant 20A087, the Innovation Platform Open Fund Project of Hunan Provincial Education Department under Grant 20K025.
机构署名:
本校为第一且通讯机构
院系归属:
信息与电子工程学院
摘要:
Identifying associations between microRNAs (miRNAs) and diseases is very important to understand the occurrence and development of human diseases. However, these existing methods suffer from the following limitation: first, some disease-related miRNAs are obtained from the miRNA functional similarity networks consisting of heterogeneous data sources, i.e., disease similarity, protein interaction network, gene expression. Second, little approaches infer disease-related miRNAs depending on the network topological features without the functional s...

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