期刊论文

Liu, Chang-hui;Yang, Rong-hua

英文

Methods and Applications in Fluorescence

2050-6120

2018

6

2

024001

10.1088/2050-6120/aa86b7

The authors acknowledge financial support from the National Natural Science Foundation of China (21135001, 21405038, 21575018, 21545003, 21675042), the Foundation for Innovative Research Groups of NSFC (21521063), the Research Foundation of Education Bureau of Hunan Province, China (15B043), and the open fund of Hunan Provincial Key Lab of Dark Tea and Jin-hua (2016TP1022 (HC6120)).

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Cyanine has been widely utilized as a near infrared (NIR) fluorophore for detection of glutathione (GSH). However, the excitation of most of the reported cyanine-based probes was less than 800 nm, which inevitably induce biological background absorption and lower the sensitivity, limiting their use for detection of GSH in blood samples. To address this issue, here, a heptamethine cyanine probe (DNIR), with a NIR excitation wavelength at 804 nm and a NIR emission wavelength at 832 nm, is employed for the detection of GSH and its oxidized form (G...