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The Theoretical Three-dimensional Structure of Bacillus thuringiensis Cry5Aa and Its Biological Implications

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成果类型:
期刊论文
作者:
Xin-Min, Zhao;Li-Qiu, Xia*;Xue-Zhi, Ding;Fa-Xiang, Wang
通讯作者:
Li-Qiu, Xia
作者机构:
[Li-Qiu, Xia; Xue-Zhi, Ding; Xin-Min, Zhao; Fa-Xiang, Wang] Hunan Normal Univ, Key Lab Microbial Mol Biol Hunan Prov, Coll Life Sci, Changsha 410081, Hunan, Peoples R China.
[Xin-Min, Zhao] Hunan City Univ, Dept Environm Chem & Engn, Yiyang 413000, Peoples R China.
通讯机构:
[Li-Qiu, Xia] H
Hunan Normal Univ, Key Lab Microbial Mol Biol Hunan Prov, Coll Life Sci, Changsha 410081, Hunan, Peoples R China.
语种:
英文
关键词:
Three-dimensional structure;Homology modeling;Cry5Aa;Bacillus thuringiensis
期刊:
PROTEIN JOURNAL
ISSN:
1572-3887
年:
2009
卷:
28
期:
2
页码:
104-110
基金类别:
National Natural Science Foundation of China [30670052, 30570050]; 863 Program of China [2006AA02Z187, 2006AA10A212]
机构署名:
本校为其他机构
院系归属:
材料与化学工程学院
摘要:
Cry5Aa is a crystal protein produced by Bacillus thuringiensis serovar. damstadiensis during its stationary phase, this δ-endotoxin is active against nematodes and has great potential for nematodes control. The theoretical model of the three-dimensional structure of Cry5Aa was predicted by homology modeling on the structures of the Cry1Aa which is specific to Lepidopteran insects. The structure of the Cry5Aa resembles previously reported Cry toxin structures but shows the following distinctions. Cry5Aa has a long insertion in α2 of domain I. ...

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