A Polymeric Nanobeacon for Monitoring the Fluctuation of Hydrogen Polysulfides during Fertilization and Embryonic Development

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成果类型：

期刊论文

作者：

Zhou, Yibo;Gu, Zhengxuan;Liu, Changhui;Yang, Sheng*;Ma, Xiaofei;...

通讯作者：

Qing, ZH;Yang, Sheng;Yang, RH

作者机构：

[Ma, Xiaofei; Qing, Zhihe; Gu, Zhengxuan; Lei, Yanli; Zhou, Yibo; Quan, Ke] Changsha Univ Sci & Technol, Hunan Prov Key Lab Cytochem, Sch Chem & Chem Engn, Sch Food & Bioen Engn, Changsha 410114, Peoples R China.

[Yang, Sheng; Yang, Ronghua] Nan Normal Univers, Lab Chem Biol & Tradit Chinese Med Res, Minist Educ, Coll Chem & Chem Engn, Changsha 410081, Peoples R China.

[Liu, Changhui] Hunan City Univ, Coll Mat & Chem Engn, Yiyang 413000, Peoples R China.

[Chen, Qiaoshu; Liu, Juewen] Univ Waterloo, Waterloo Inst Nanotechnol, Dept Chem, Waterloo, ON N2L 3G1, Canada.

通讯机构：

[Yang, S; Yang, RH ] N

[Qing, ZH ] C

Changsha Univ Sci & Technol, Hunan Prov Key Lab Cytochem, Sch Chem & Chem Engn, Sch Food & Bioen Engn, Changsha 410114, Peoples R China.

Nan Normal Univers, Lab Chem Biol & Tradit Chinese Med Res, Minist Educ, Coll Chem & Chem Engn, Changsha 410081, Peoples R China.

语种：

英文

关键词：

Embryonic Development;Fluorescence Imaging;Hydrogen Polysulfides;Polymeric Nanobeacon;Signal Amplification

期刊：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ISSN：

1433-7851

年：

2022

卷：

期：

页码：

e202114504-

DOI：

10.1002/anie.202114504

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21735001, 21804012, 21974013, 22074008]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ30025]; Natural Sciences and Engineering Research Council of Canada (NSERC)Natural Sciences and Engineering Research Council of Canada (NSERC)

机构署名：

本校为其他机构

院系归属：

材料与化学工程学院

摘要：

Fertilization and early embryonic development as the beginning of a new life are key biological events. Hydrogen polysulfide (H2Sn) plays important roles during physiological regulation, such as antioxidation-protection. However, no report has studied in situ H2Sn fluctuation during early embryonic development because of the low abundance of H2Sn and inadequate sensitivity of probes. We herein construct a polymeric nanobeacon from a H2Sn-responsive polymer and fluorophores, which is capable of detecting H2Sn selectively and of signal amplificat...

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A Polymeric Nanobeacon for Monitoring the Fluctuation of Hydrogen Polysulfides during Fertilization and Embryonic Development

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