The supercontinuum generation and manipulation of Airy-Gaussian pulses in a photonic crystal fiber with three zero-dispersion points are studied using the split-step Fourier method. Firstly, the spectral evolution of Airy-Gaussian pulses in four photonic crystal fibers with different barrier widths was discussed, and the optimal fiber was determined after considering the factors of width and flatness. By analyzing the mechanism of supercontinuum generation in photonic crystal fibers with single, double and three zero-dispersion points, it is found that the photonic crystal fiber with three zer...