This paper focused on the changes of neuropeptide substance level and its effects on bone mineral density, by using the method of cutting off the nerves and fixing the hind legs Finally we found that calcitonin gene-related peptide levels and bone mineral density decreased after denervation Besides, calcitonin gene-related peptide levels were highly related to changes in bone mineral density It was proved that integrity of nerves was the key to maintain the level of calcitonin gene-related peptide Dynamic observation of calcitonin gene-related peptide level changes, to some extent, could predi...