A novel p-acetaminophen resin (named as GQ-1) was synthesized with chloromethylated polystyrene and p-acetaminophen. It can be used without any wetting process. The objective of this work was to study the adsorption performances for vanillin onto GQ-1 with two kinds of the hydrogen bond site of acetamino group and hydroxyl group. The results showed that the adsorption property of vanillin onto GQ-1 was superior to XAD-4, H103, NDA150, and NDA88. The adsorption capacity of vanillin onto GQ-1 is not greatly discrepant until the solution pH is higher than 5.31. The saturated adsorption quantity o...