This article proposes a seismic optimization strategy to reduce the cost of piers of simply-supported bridges for high-speed railway (HSR) in China. The dimension and reinforcement ratio of piers are defined as variables. The running safety of high-speed trains during normal operation is considered by novelly setting the vibration amplitude of running trains to satisfy the corresponding constraint condition. Other constraint conditions include the structural fundamental frequency, buckling stability, and longitudinal stiffness, as well as the s...