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Theanine Improves High-Dose Epigallocatechin-3-Gallate-Induced Lifespan Reduction in Caenorhabditis elegans

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成果类型:
期刊论文
作者:
Peng, Yuxuan;Dai, Shen;Lu, Yan;Xiong, Ligui;Huang, Jianan;...
作者机构:
[Peng, Yuxuan; Lu, Yan; Liu, Zhonghua; Xiong, Ligui; Gong, Yushun] Hunan Agr Univ, Natl Res Ctr Engn & Technol Utilizat Bot Funct In, Changsha 410128, Peoples R China.
[Peng, Yuxuan] Hunan City Univ, Coll Phys Educ, Yiyang 413002, Peoples R China.
[Dai, Shen; Gong, Yushun; Huang, Jianan] Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Peoples R China.
[Liu, Zhonghua] Hunan Agr Univ, Collaborat Innovat Ctr Utilizat Funct Ingredients, Changsha 410128, Peoples R China.
语种:
英文
关键词:
theanine;EGCG;hormesis;Reactive Oxygen Species (ROS);DAF-16
期刊:
Foods
ISSN:
2304-8158
年:
2021
卷:
10
期:
6
页码:
1404
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [32072155]; Project of Education Department in Hunan [18A101]; double first-class construction project of Hunan Agricultural University [SYL2019013]; NIH Office of Research Infrastructure ProgramsUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [P40 OD010440]
机构署名:
本校为其他机构
院系归属:
体育学院
摘要:
Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea. Our previous report showed that induced hormesis was a critical determinant for the promotion of a healthy lifespan in Caenorhabditis elegans. In the present study, we investigated the anti-aging effects of the main active ingredients in green tea. We found that galloylated catechins (EGCG and epicatechin gallate) could extend the lifespan of C. elegans, while their metabolites (gallic acid, epicatechin, and epigallocatechin) could not. Interestingly, the combination with theanine, not caffeine, could alleviate the...

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