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Theanine Improves High-Dose Epigallocatechin-3-Gallate-Induced Lifespan Reduction in Caenorhabditis elegans

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成果类型:
期刊论文
作者:
Peng, Yuxuan;Dai, Shen;Lu, Yan;Xiong, Ligui;Huang, Jianan;...
通讯作者:
Gong, Y.;Liu, Z.
作者机构:
[Peng, Yuxuan; Lu, Yan; Liu, Zhonghua; Xiong, Ligui; Gong, Yushun] Hunan Agr Univ, Natl Res Ctr Engn & Technol Utilizat Bot Funct In, Changsha 410128, Peoples R China.
[Peng, Yuxuan] Hunan City Univ, Coll Phys Educ, Yiyang 413002, Peoples R China.
[Dai, Shen; Gong, Yushun; Huang, Jianan] Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Peoples R China.
[Liu, Zhonghua] Hunan Agr Univ, Collaborat Innovat Ctr Utilizat Funct Ingredients, Changsha 410128, Peoples R China.
通讯机构:
[Zhonghua Liu; Yushun Gong] A
Authors to whom correspondence should be addressed.<&wdkj&>National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Collaborative Innovation Center of Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China
语种:
英文
关键词:
theanine;EGCG;hormesis;Reactive Oxygen Species (ROS);DAF-16
期刊:
Foods
ISSN:
2304-8158
年:
2021
卷:
10
期:
6
页码:
1404-
基金类别:
Conceptualization, Y.G. and Z.L.; methodology, Y.P. and S.D.; software, Y.L. and Y.P.; data curation, L.X.; writing—original draft preparation, Y.P.; writing—review and editing, Y.P.; supervision, J.H.; funding acquisition, Y.G. All authors have read and agreed to the published version of the manuscript. This work was supported by the National Natural Science Foundation of China (No. 32072155), the Project of Education Department in Hunan (No. 18A101), and the double first-class construction project of Hunan Agricultural University (No. SYL2019013). C. elegans strains and E. coli OP50 were provided by the CGC, which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440).
机构署名:
本校为其他机构
院系归属:
体育学院
摘要:
Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea. Our previous report showed that induced hormesis was a critical determinant for the promotion of a healthy lifespan in Caenorhabditis elegans. In the present study, we investigated the anti-aging effects of the main active ingredients in green tea. We found that galloylated catechins (EGCG and epicatechin gallate) could extend the lifespan of C. elegans, while their metabolites (gallic acid, epicatechin, and epigallocatechin) could not. Interestingly, the combination with theanine, not caffeine, could alleviate the...

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