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Three-Component Synthesis of Dibenzoxazepinamines and Dibenzothiazepinamines under Transition-Metal-Free Conditions

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成果类型:
期刊论文
作者:
Fang, Fang;Jiang, Shuxin;Lei, Hanwen;Chen, Shanping*;Deng, Guo-Jun*
通讯作者:
Chen, Shanping;Deng, Guo-Jun
作者机构:
[Fang, Fang; Jiang, Shuxin; Chen, Shanping; Deng, Guo-Jun; Chen, SP; Deng, GJ; Lei, Hanwen] Xiangtan Univ, Coll Chem, Minist Educ,Key Lab Green Organ Synth & Applicat, Key Lab Environm Friendly Chem & Applicat, Xiangtan 411105, Peoples R China.
[Fang, Fang] Hunan City Univ, Coll Mat & Chem Engn, Yiyang 413000, Peoples R China.
通讯机构:
[Chen, SP; Deng, GJ] X
Xiangtan Univ, Coll Chem, Minist Educ,Key Lab Green Organ Synth & Applicat, Key Lab Environm Friendly Chem & Applicat, Xiangtan 411105, Peoples R China.
语种:
英文
关键词:
Chlorine compounds;2-aminophenols;2-nitrobenzaldehyde;Component approaches;Component synthesis;Condition;Efficient strategy;Gram-scale synthesis;Metal-free conditions;Simple++;Three-component;Transition metals;7 bromodibenzo[b,f][1,4]thiazepin 11 amine;7 chlorodibenzo[b,f][1,4]oxazepin 11 amine;7 chlorodibenzo[b,f][1,4]thiazepin 11 amine;7 methoxydibenzo[b,f][1,4]thiazepin 11 amine;7 methyldibenzo[b,f][1,4]oxazepin 11 amine;7 methyldibenzo[b,f][1,4]thiazepin 11 amine;7,8 dimethyldibenzo[b,f][1,4]oxazepin 11 amine;8 (tert butyl)dibenzo[b,f][1,4]oxazepin 11 amine;8 bromodibenzo[b,f][1,4]oxazepin 11 amine;8 chlorodibenzo[b,f]1,4]oxazepin 11 amine;8 chlorodibenzo[b,f][1,4]thiazepin 11 amine;8 fluorodibenzo[b,f][1,4]oxazepin 11 amine;8 methoxydibenzo[b,f][1,4]oxazepin 11 amine;8 methyldibenzo[ b,f ][1,4]oxazepin 11 amine;8 methyldibenzo[b,f][1,4]thiazepin 11 amine;8 phenyldibenzo[b,f][1,4]oxazepin 11 amine;9 chlorodibenzo[b,f][1,4]thiazepin 11 amine;9 methyldibenzo[b,f][1,4]oxazepin 11 amine;amine;benzo[f]naphthol[2,3 b][1,4]oxazepin 13 amine;dibenzothiazepinamine;dibenzoxazepinamine;dibenzo[b,f][1,4]oxazepin 11 amine;dibenzo[b,f][1,4]thiazepin 11 amine;methyl 11 aminodibenzo[b,f][1,4]oxazepine 8 carboxylate;transition element;unclassified drug;Article;chemical reaction;controlled study;drug synthesis;one pot synthesis;reaction analysis;reaction temperature
期刊:
JOURNAL OF ORGANIC CHEMISTRY
ISSN:
0022-3263
年:
2021
卷:
86
期:
21
页码:
15658-15664
基金类别:
We are grateful for financial support from the National Natural Science Foundation of China (21871226, 21572194) and the Collaborative Innovation Center of New Chemical Technologies for Environmental Benignity and Efficient Resource Utilization.
机构署名:
本校为其他机构
院系归属:
材料与化学工程学院
摘要:
A convenient and efficient strategy for the synthesis of dibenzoxazepinamines and dibenzothiazepinamines has been developed. This three-component approach started from 2-nitrobenzaldehydes, 2-aminophenols, and methoxyammonium chlorides under metal-free conditions. The protocol has the advantages of readily available starting materials, simple and facile conditions, gram-scale synthesis, and broad substrate scope, providing an efficient and practical strategy for the preparation of potential drug-active dibenzoxazepinamines and...

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