期刊论文

Li, Z.-H.

中文

Chinese Journal of Tissue Engineering Research

1673-8225

2009

13

20

3933-3937

10.3969/j.issn.1673-8225.2009.20.028

湖南省教育厅资助课题（04C170）~~；

本校为第一且通讯机构

背景:大量研究认为降钙素基因相关肽具有刺激成骨、增加骨量,促进神经再生等诸多功能,然而不同制动后降钙素基因相关肽的变化规律及对骨质疏松形成过程中的作用和机制至今仍不十分清楚.目的:观察失神经固定后神经肽物质对大鼠骨密度的影响及其可能机制.设计、时间及地点:随机对照动物实验,于2006-09/11在湘南学院附属医院完成.材料:10周龄SD雄性大鼠96只.体质量220～250 g,用于制备失神经支配模型.方法:96只SD大鼠按数字表法随机分为3批,每批4组,每组8只.失神经支配组:大鼠麻醉后,先于俯卧位行两侧后肢股外侧切口,于股骨转子水平切断双侧坐骨神经;再置大鼠于仰卧位,行两侧股正中纵切1:3,于腹股沟...

BACKGROUND: It is believed that calcitonin-gene-related peptide (CGRP) can stimulate osteoblast proliferation, increase bone mass, and promote nerve regeneration. However, the change rule, effect and mechanism of CGRP on osteoporosis formation after different immobilization remain unclear. OBJECTIVE: To observe the effect, as well as possible mechanism of neuropeptide on bone mineral density (BMD) after denervation and immobilization. DESIGN, TIME AND SETTING: The Randomized controlled animal experiment was completed in the Affiliated Hospital of Xiangnan University from September to November ...