期刊论文

Li, Z.-H.

中文

Chinese Journal of Tissue Engineering Research

1673-8225

2009

13

33

6428-6432

10.3969/j.issn.1673-8225.2009.33.004

湖南省教育立项课题（04C170）~~；

本校为第一且通讯机构

以往研究认为，刺激坐骨神经及中枢神经受伤可使神经肽Y 含量发生改变，神经肽Y 对破骨细胞产生作用，影响骨代谢。目的：验证双侧坐骨神经、股神经失神经及固定后神经肽物质对大鼠双侧胫骨骨密度的影响，并进行相关性分析。设计、时间及地点：随机对照动物实验，于2006-09/11 在湘南学院附属医院完成。材料：10 周龄SD 雄性大鼠96只，体质量220～250 g，用于制备失神经支配模型。方法：96 只SD 大鼠按数字表法随机分为3 组，每组32 只。①失神经支配组：切断大鼠两侧后肢坐骨神经和两侧股神经，远端游离5 mm，缝合切口。②固定组：大鼠切断神经，程序同前，继之采用管型石膏固定。③对照组：行...

BACKGROUND: Previous studies have showed that stimulating the sciatic nerve and central nerve injury may alter the content of neuropeptide Y (NPY), which influences the osteoclasts and bone metabolism. OBJECTIVE: To observe the effect of NPY on bone mineral density (BMD) after bilateral sciatic denervation and immobilization, and to perform the correlation analysis. DESIGN, TIME AND SETTING: Randomized controlled animal experiment was completed in the Affiliated Hospital of Xiangnan University from September to November in 2006. MATERIALS: Ninety-six male Sprague Dawley rats, aged 10 weeks, we...