The manganese in gasoline was determined by microwave digestion and graphite furnance atomic absorption spectroscopy (GF AAS). Orthogonal experiment design of 4 factors, including time,temperature,power and amount of nitric acid, at 2 levels was applied for optimizing parameters of microwave digestion. The optimizing conditions of microwave digestion was established. The Mn in gasoline showed that the relative standard deviation (n-= 11) was lower than 4.12% and the recovery of Mn (standrad addition method) was 96.5%-110. 2%. The method h...