期刊论文

Xia Li Qui

英文

生物医学与环境科学(英文)

0895-3988

2012

25

5

590-596

10.3967/0895-3988.2012.05.014

∗This research was supported by grants from Hunan Provincial Natural Science Foundation of China (No.12JJ3021), the National Natural Science Foundation of China (No.30670052, 30570050) and 863 Program of China (2006AA02Z187). #Correspondence should be addressed to XIA Li Qui. Tel: 86 ?73818 ?872905. Fax: 86 ?73818 ?872298. E ?mail: xialq@hunnu.edu.cn Biographical note of the first author: ZHAO Xin Min, male, born in 1962, Ph. D, majoring in microbial molecular biology. Received: July 10, 2011; Accepted: March 15, 2012

本校为其他机构

Objective: To investigate the theoretical model of the three-dimensional structure of mosquitocidal Cry30Ca2 and its molecular docking with N-acetylgalactosamine. Methods: The theoretical model of Cry30Ca2 was predicted by homology modeling on the structure of the Cry4Ba. Docking studies were performed to investigate the interaction of Cry30Ca2 with N-acetylgalactosamine on the putative receptor. Results: Cry30Ca2 toxin is a rather compact molecule composed of three distinct domains and has approximate overall dimensions of 95 by 75 by 60Å. Do...

目的将调查 mosquitocidal Cry30Ca2 并且它与 N-acetylgalactosamine 的分子的停靠的三维的结构的理论模型。Cry30Ca2 的理论模型被在 Cry4Ba 的结构上当模特儿的相同预言的方法。停靠研究被执行在通常认为的受体上与 N-acetylgalactosamine 调查 Cry30Ca2 的相互作用。结果 Cry30Ca2 毒素是由三个不同领域组成的一个相当紧缩的分子并且在 60 在 75 有 95 的近似全面尺寸 ? 。领域 II 是螺旋捆，领域 II 由三反平行的 -sheets, 领域 III 组成由采用三明治褶层的二张表组成。在在 loop2 的 loop1，残余 342Gln 343Thr 和 345Gln 的残余 321Ile，在 Cry30Ca2 的 loop3 的残余 393Tyr 为和经由 7 ...