A new effective fluorescent sensor based on rhodamine was synthesized, which was induced by Cu 2 in aqueous media to produce turn-on fluorescence. The new sensor 1 exhibited good selectivity for Cu 2 over other heavy and transition metal (HTM) ions in H 2O/CH 3CN(7:3, v/v). Upon addition of Cu 2, a remarkable color change from colorless to pink was easily observed by the naked eye, and the dramatic fluorescence turn-on was corroborated. Furthermore, kinetic assay indicates that sensor 1 could be used for real-time tracking of Cu 2 in cells and ...