Silver nanoparticle gated, mesoporous silica coated gold nanorods (AuNR@MS@AgNPs): Low premature release and multifunctional cancer theranostic platform

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成果类型：

期刊论文

作者：

Zhang, Zhehua;Liu, Changhui;Bai, Junhui;Wu, Cuichen;Xiao, Yue;...

通讯作者：

Zheng, Jing

作者机构：

[Liu, Changhui; Xiao, Yue; Bai, Junhui; Zheng, Jing; Yang, Ronghua; Li, Yinhui; Zhang, Zhehua; Tan, Weihong] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

[Liu, Changhui] Hunan City Univ, Dept Chem & Environm Engn, Yiyang 413000, Peoples R China.

[Yang, Ronghua] Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Changsha 410004, Hunan, Peoples R China.

[Wu, Cuichen; Tan, Weihong] Univ Florida, Dept Chem, Ctr Res Bio Nano Interface, Gainesville, FL 32611 USA.

[Wu, Cuichen; Tan, Weihong] Univ Florida, Dept Physiol & Funct Genom, Shands Canc Ctr, Gainesville, FL 32611 USA.

通讯机构：

[Zheng, Jing] H

Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

语种：

英文

关键词：

mesoporous silica nanoparticles;gold nanorods;silver nanoparticle;GSH;photothermal therapy;photodynamic therapy

期刊：

ACS Applied Materials & Interfaces

ISSN：

1944-8244

年：

2015

卷：

期：

页码：

6211-6219

DOI：

10.1021/acsami.5b00368

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21405038, 21135001, 21305036]; Foundation for Innovative Research Groups of NSFCNational Natural Science Foundation of China (NSFC) [21221003]; "973" National Key Basic Research ProgramNational Basic Research Program of China [2011CB91100-0]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities

机构署名：

本校为其他机构

院系归属：

材料与化学工程学院

摘要：

Multifunctional nanoparticles integrated with an imaging module and therapeutic drugs are promising candidates for future cancer diagnosis and therapy. Mesoporous silica coated gold nanorods (AuNR@MS) have emerged as a novel multifunctional cancer theranostic platform combining the large specific surface area of mesoporous silica, which guarantees a high drug payload, and the photothermal modality of AuNRs. However, premature release and side effects of exogenous stimulus still hinder the further application of AuNR@MS. To address these issues,...

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Silver nanoparticle gated, mesoporous silica coated gold nanorods (AuNR@MS@AgNPs): Low premature release and multifunctional cancer theranostic platform

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