In this paper, the application of chemometrics coupled with high-performance liquid chromatography-diode array detection (HPLC–DAD)for the rapid and sensitive quantitativeanalysis of seven flavonoids in the raw and purified propolis samples was investigated.The objective of this paper was to receive a successful resolution of the complex propolis matrix with minimum experimental time (3.5min) when appearing unknown interferences, highly overlapping peaks, time and baseline drifts among chromatograms. First, the validation samples contained sev...