In the super-resolution microscopy imaging technology, single molecule localization microscopy is one of the widely used techniques. In this paper, in order to achieve super-resolution fluorescence image reconstruction, a multiple measurement vector Compressed sensing (MMV-CS) model was established based on the principle of fluorescence microscopic imaging, and the multiple sparse Bayesian learning algorithm was applied in problem solving. The effects of the effective pixel size, the number of photons generated by fluorescent molecules and the ...