Reasonable assessment of long-term prestress loss and crack resistance is essential to ensure the service performance of prestressed concrete (PC) bridges. In this paper, a novel prediction model of long-term prestress loss considering the coupling effect of shrinkage and creep of concrete, prestressing steel relaxation, and presence of nonprestressing steel as well as the corrosion of prestressing and nonprestressing steel is proposed. Then, the probability analysis approach of long-term prestress loss considering the uncertainties of calculation parameters and models is introduced. Moreover,...