期刊论文

Wen, R.-M.(wenruiming@sohu.com)

中文

中南大学学报(自然科学版)

1672-7207

2012

43

4

1249-1253

国家自然科学基金资助项目（51074069）； 湖南省科技计划项目（2009SK4027）；

本校为第一且通讯机构

在对甲苯磺酸催化下,将芳香醛与芳胺于室温下研磨可得较高收率的苯甲醛缩苯胺衍生物,通过单因素实验研究研磨时间、对甲苯磺酸用量及取代基类型对缩合反应的影响。研究结果表明采用对甲苯磺酸催化研磨法合成苯甲醛缩苯胺衍生物最佳工艺条件是：芳香醛、芳胺、对甲苯磺酸的摩尔比为100：100：3,反应温度为室温,研磨时间为1~3 min,在此条件下,反应收率可达86.5%~95.5%,比采用溶剂回流法和常规研磨法所得收率有显著提高,而且反应时间减少0.5%;芳醛环上取代基对反应无影响,但芳胺环上邻、对位的强吸电子基抑制反应的进行;与传统方法相比,对甲苯磺酸催化研磨法具有反应时间短、条件温和、操作简单、收...

Condensation of aromatic aldehydes with arylamines catalyzed by p-toluene sulfonic acid (PTSA) was carried out at room temperature to obtain benzalaniline by grinding. The factors that affect the condensation including grinding time, the amount of PTSA and the type of substituents were studied by single factor test. The results show that the optimal conditions of condensation catalyzed p-toluene sulfonic acid using grinding method are as follows. The mole ratio of aromatic aldehyde, arylamine and PTSA is 100:100:3, the reaction temperature is room temperature, and the grinding time is 1-3 min....