Determination of volatile components in drug pair (DP) Herba Ephedrae-Rhizoma seu Radix Notopeterygii (HE-RsRN), single drug HE and RsRN was performed using two-dimensional gas chromatography-mass spectrometry (GC-MS) data coupled with chemometric resolution method (CRM). With the help of CRM, the two-dimensional data obtained from GC-MS instruments were resolved into a pure chromatogram and a mass spectrum of each chemical compound. Using these methods to process two-dimensional data, 51, 52, and 58 volatile chemical components in essential oil of HE, RsRN, and DP HE-RsRN were respectively de...