期刊论文

Synthesis and application of(R)-1-(3-(dibenzylmethylamino)-2-hydroxypropyl)-1-methylpiperidine ammonium iodide

中文

湖南城市学院学报(自然科学版)

1672-7304

2023

32

02

68-72

10.3969/j.issn.1672-7304.2023.02.0011

湖南省教育厅科研项目(22A0553)。

本校为第一机构

首先,以二苄胺和(R)-环氧氯丙烷为原料合成了(R)-3-二苄胺基-1,2-环氧丙烷,再与哌啶反应合成了(R)-1-二苄胺基-3-哌啶基-2-丙醇(ligand 1),并研究了ligand 1诱导二乙基锌对苯甲醛的对映选...展开更多 首先,以二苄胺和(R)-环氧氯丙烷为原料合成了(R)-3-二苄胺基-1,2-环氧丙烷,再与哌啶反应合成了(R)-1-二苄胺基-3-哌啶基-2-丙醇(ligand 1),并研究了ligand 1诱导二乙基锌对苯甲醛的对映选择性加成反应;其次,用(R)-1-二苄胺基-3-哌啶基-2-丙醇和碘甲烷反应合成了(R)-1-(3-(二苄基甲基氨基)-2-羟丙基)-1-甲基哌啶碘化铵(ligand 2),同时研究了ligand 2在不对称相转移催化反应中的应用,并利用核磁共振...

(R)-1-(dibenzylamino)-3-(piperidin-1-yl)propan-2-ol(ligand 1)was obtained by the reaction of piperidine with(R)-3-dibenzylamine-1,2-epoxy propane which was synthesized from dibenzyl amine and(R)-epichlorohydrin.Then,the ligand 1 was used to induce asymmetric addition of...MORE (R)-1-(dibenzylamino)-3-(piperidin-1-yl)propan-2-ol(ligand 1)was obtained by the reaction of piperidine with(R)-3-dibenzylamine-1,2-epoxy propane which was synthesized from dibenzyl amine and(R)-epichlorohydrin.Then,the ligand 1 was used to induce asymmetric addition of diethyl zinc to benzaldehyde.And then,the correspon...