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Development of a near-infrared fluorescence turn-on probe for imaging Hg2+in living cells and animals

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成果类型:
期刊论文
作者:
Wang, Jiaoliang;Li, Weiling;Long, Liping*
通讯作者:
Long, Liping
作者机构:
[Wang, Jiaoliang; Long, Liping] Hunan City Univ, Coll Chem & Environm Engn, Yiyang 413000, Hunan, Peoples R China.
[Li, Weiling] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.
通讯机构:
[Long, Liping] H
Hunan City Univ, Coll Chem & Environm Engn, Yiyang 413000, Hunan, Peoples R China.
语种:
英文
关键词:
CS dye;Mercury ion;NIR fluorescent probe;Vivo imaging
期刊:
Sensors and Actuators B-Chemical
ISSN:
0925-4005
年:
2017
卷:
245
页码:
462-469
基金类别:
NSFCNational Natural Science Foundation of China (NSFC) [21502048, 21545003]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2016JJ3102, 2015JJ2023]; outstanding youth project of the Education Department of Hunan Province [14B036]; Science and Technology Innovative Research Team in Higher Educational Instituions of Hunan Province
机构署名:
本校为第一且通讯机构
院系归属:
材料与化学工程学院
摘要:
Mercury is one of the deadly toxic metals to humans. A new fluorescent probe CS-Hg for Hg2+has been designed and synthesized based on the Hg2+-promoted cyclization and the CS NIR platform. The probe upon interaction with different metal ions showed good sensitivity and high selectivity for Hg2+through fluorescence “turn-on”response in PBS buffer. Significantly, the probe CS-Hg is highly reactive to Hg2+with a very rapid response. Furthermore, we have demonstrated that the probe is applicable for Hg2+imaging in the living cells and in animals. ©201...

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