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Construction of Riboswitches for Screening Antibacterial Agents from Forest Plants

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成果类型:
期刊论文
作者:
Liu, Zhanjun;Li, Taotao;Zhang, Xingyu;Liu, Shiquan;Hu, Zhiyuan;...
通讯作者:
Li, TT
作者机构:
[Zhou, Xiaohong; Liu, Shiquan; Yu, Songlin; Hu, Zhiyuan; Liu, Zhanjun; Li, Taotao; Zhang, Xingyu; Li, TT] Hunan City Univ, Hunan Prov Key Lab Dark Tea & Jin Hua, Yiyang 413000, Peoples R China.
通讯机构:
[Li, TT ] H
Hunan City Univ, Hunan Prov Key Lab Dark Tea & Jin Hua, Yiyang 413000, Peoples R China.
语种:
英文
关键词:
plant bioactive components;antibacterial target;non-coding RNA;antibiotic resistance;functional nucleic acid material
期刊:
Forests
ISSN:
1999-4907
年:
2024
卷:
15
期:
2
基金类别:
Research Foundation of the Education Bureau of Hunan Province
机构署名:
本校为第一且通讯机构
摘要:
Forest plants contain abundant natural products, providing a valuable resource for obtaining compounds with various functional activities, such as antimicrobial, lipid-lowering, and immunoregulatory activities. The development of efficient tools for rapidly screening functional natural products from forest plants is essential for human health. In this study, we constructed some transgenic strains (Escherichia coli) containing Ahy1-1 riboswitches that respond to cyclic di-guanylate (c-di-GMP), serving as a novel bacteriostatic target. The Ahy1-1 riboswitches contained the LacZ gene (encoding be...

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