期刊论文

The influence on accuracy of respiratory mechanics estimation with different inspiratory effort during noninvasive ventilation: a bench study

中文

中国呼吸与危重监护杂志

1671-6205

2021

20

10

715-720

10.7507/1671-6205.202104021

上海交通大学“交大之星”医工交叉研究基金（G2019ZDB08）；

本校为其他机构

目的应用动态信号分析法评估无创正压通气(NPPV)时不同吸气努力对肺力学模型呼吸力学参数测算的影响。方法选择ASL5000机械模拟肺模拟体重为65~70 kg的半卧位健康成年人、慢性阻塞性肺疾病和急性呼吸窘迫综合征患者。吸气压力(P_(mus))分别为0、5.0、10.0和15.0 cm H_(2)O。Respironics V60呼吸机以自主/时间控制模式运行,呼气末正压为5.0 cm H_(2)O,调整P_(mus)使呼吸机输出潮气量为7.0 mL/kg,后备通气频率为10次/min。收集系统泄漏量为25~28 L/min时的通气参数变化并计算呼吸力学参数系统顺应性(C_(rs))和气道阻力(Raw)。结果随着P_(mus)增大,三种肺力学模型的驱动压(DP)逐渐减小;P_(mus)超过...

Objective To evaluate the influence on the estimation of respiratory mechanics with dynamic signal analysis approach during noninvasive positive pressure ventilation (NPPV) under different inspiratory effort conditions. Methods The Respironics V60 ventilator was connected to a ASL5000 lung simulator, which simulate lung mechanics in healthy adults with body weight from 65 to 70 kg, and patients with chronic obstructive pulmonary disease (COPD) and acute respiratory distress (ARDS). Each lung models was subjected to 4 different muscle pressures ...