期刊论文

Cao, Buwen;Deng, Shuguang

英文

Molecules

1420-3049

2018

23

6

1460

10.3390/molecules23061460

Author Contributions: Conceptualization: B.C. and S.D.; data curation: S.C.; formal analysis: S.D.; investigation: S.C.; methodology: B.C.; project administration: S.D.; resources: P.D.; software: S.C.; supervision: S.D.; Funding: This research was funded by the National Natural Science Foundation of China grant numbers [61572180, 61472467,validation:61471164,B.C., H.Q.61672011,, and G.Land.; writing61602164],-originalthedraft:HunanB.C.;Provincialwriting-Naturalreview & eScienceditingFoundation: P.D. of China grant numbers [2016JJ2012 and 2018JJ2024], the Key Project of the Education Department of Hunan Province grant Funding: This research was funded by the National Natural Science Foundation of China grant numbers number [17A037], and the Scientific and Technological Research Project of Education Department in Jiangxi [61572180, 61472467, 61471164, 61672011, and 61602164], the Hunan Provincial Natural Science Foundation of China grant numbers [2016JJ2012 and 2018JJ2024], the Key Project of the Education Department of Hunan Conflicts of Interest: The authors declare no conflict of interest. Province grant number [17A037], and the Scientific and Technological Research Project of Education Department in Jiangxi Province grant number [GJJ170383]. This research was funded by the National Natural Science Foundation of China grant numbers [61572180, 61472467, 61471164, 61672011, and 61602164], the Hunan Provincial Natural Science Foundation of China grant numbers [2016JJ2012 and 2018JJ2024], the Key Project of the Education Department of Hunan Province grant number [17A037], and the Scientific and Technological Research Project of Education Department in Jiangxi Province grant number [GJJ170383].

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High-throughput technology has generated large-scale protein interaction data, which is crucial in our understanding of biological organisms. Many complex identification algorithms have been developed to determine protein complexes. However, these methods are only suitable for dense protein interaction networks, because their capabilities decrease rapidly when applied to sparse protein-protein interaction (PPI) networks. In this study, based on penalized matrix decomposition (PMD), a novel method of penalized matrix decomposition for the identi...