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Detection of Protein Complexes Based on Penalized Matrix Decomposition in a Sparse Protein-Protein Interaction Network

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成果类型:
期刊论文
作者:
Cao, Buwen*;Deng, Shuguang*;Qin, Hua;Ding, Pingjian;Chen, Shaopeng;...
通讯作者:
Cao, Buwen;Deng, Shuguang
作者机构:
[Qin, Hua; Cao, Buwen; Deng, Shuguang] Hunan City Univ, Coll Informat & Elect Engn, Yiyang 413000, Peoples R China.
[Cao, Buwen; Li, Guanghui; Ding, Pingjian] Hunan Univ, Coll Comp Sci & Elect Engn, Changsha 410082, Hunan, Peoples R China.
[Chen, Shaopeng] Hunan Normal Univ, Coll Math & Comp Sci, Changsha 410081, Hunan, Peoples R China.
[Li, Guanghui] East China Jiaotong Univ, Sch Informat Engn, Nanchang 330013, Jiangxi, Peoples R China.
通讯机构:
[Cao, BW; Deng, SG; Cao, Buwen] H
Hunan City Univ, Coll Informat & Elect Engn, Yiyang 413000, Peoples R China.
Hunan Univ, Coll Comp Sci & Elect Engn, Changsha 410082, Hunan, Peoples R China.
语种:
英文
关键词:
clustering;penalized matrix decomposition;protein complex;protein-protein interaction (PPI)
期刊:
Molecules
ISSN:
1420-3049
年:
2018
卷:
23
期:
6
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61572180, 61472467, 61471164, 61672011, 61602164]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2016JJ2012, 2018JJ2024]; Key Project of the Education Department of Hunan Province [17A037]; Scientific and Technological Research Project of Education Department in Jiangxi Province [GJJ170383]
机构署名:
本校为第一且通讯机构
院系归属:
信息与电子工程学院
摘要:
High-throughput technology has generated large-scale protein interaction data, which is crucial in our understanding of biological organisms. Many complex identification algorithms have been developed to determine protein complexes. However, these methods are only suitable for dense protein interaction networks, because their capabilities decrease rapidly when applied to sparse protein-protein interaction (PPI) networks. In this study, based on penalized matrix decomposition (PMD), a novel method of penalized matrix decomposition for the identi...

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